The Boston Red Sox will look to extend their winning streak to 11 games when they take on the Chicago Cubs in a key interleague matchup on Friday afternoon. Chicago enters the second half of the season on a modest two-game win streak. The Red Sox (53-45), who are third in the American League East, are 21-25 on the road this season. The Cubs (57-39), who are first in the National League Central, are 30-16 on their home field.

First pitch from Wrigley Field in Chicago is set for 2:20 p.m. ET. The Red Sox have won five of the last seven meetings with the Cubs, including three of the last four played at Wrigley. Chicago is a -137 favorite on the money line (risk $137 to win $100) in the latest Red Sox vs. Cubs odds from FanDuel Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 7.5 in the latest MLB odds. Boston's Alex Bregman is +420 to hit a home run, while Chicago's Pete Crow-Armstrong is +100 to record 2+ total bases. 

Before you make any Red Sox vs. Cubs picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 17 of the 2025 MLB season 46-43 on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 40 units of profit. Anybody following could have seen strong returns!

The model has simulated Red Sox vs. Cubs 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

Who wins Red Sox vs. Cubs, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 46-43 roll on top-rated MLB picks!