Real Madrid vs. Manchester City 2022 UEFA Champions League odds, picks: Best bets and predictions for Wednesday's showdown from soccer insider

After a scintillating first leg last week, it's all on the line Wednesday when Real Madrid hosts Manchester City in the semifinals of the 2021-22 UEFA Champions League at Santiago Bernabeu Stadium. The winner will face Liverpool or Villareal, who square off Tuesday, in the May 28 final. Man City took a 4-3 victory at the Etihad last Tuesday, and both teams are loaded with stars. Real Madrid clinched the Spanish La Liga title with a ruthless 4-0 win against Espanyol on Saturday, while City is in a battle with Liverpool for the English Premier League title.

Kickoff is set for 3 p.m. ET. Man City is listed as the +111 favorite (risk $100 to win $111) on the 90-minute money line in the latest Real Madrid vs. Manchester City odds from Caesars Sportsbook, while Real is the +215 underdog. A draw is priced at +285 and the over-under for total goals scored is 3.5.

Before betting on the Manchester City vs. Real Madrid match or making any 2022 UEFA Champions League predictions, you MUST see what soccer insider Brandt Sutton has to say.

Sutton, a former collegiate soccer player, has been SportsLine's top soccer editor for nearly five years. He has followed soccer closely for much longer and factors in managerial tactics, projected lineups and past performances to make the most-informed decisions possible, keeping his finger on the pulse of the game all over the globe.

Sutton has also been on a roll with his best bets, going 72-56 in his last 128 soccer picks, returning over $1,400 for $100 bettors!

The expert knows City is probably the deepest team in the world, with multiple scoring options and an elite back line anchored by a star goalkeeper. City has scored 16 goals in its past four games, and Gabriel Jesus is on fire. He has six goals in the past three games, including one in last week's match. Midfielder Kevin De Bruyne opened the scoring in the second minute at the Etihad last week, and he is the engine of the potent offense. He has 15 goals and 12 assists in all competitions, while five others have at least 10 goals.

Sutton also has considered that Real Madrid's Karim Benzema has been the hottest player on the planet. He scored twice on penalty kicks last week and has 42 goals in all competitions. Vinicius Junior also got on the board at the Etihad  and has 18 goals overall. The two players have combined for 30 assists. Los Blancos have scored at least two goals in 11 of their past 12 games, scoring 32 over that span. They allowed 22 in that time frame, but 11`came in just three matches. Goalkeeper Thibaut Courtouis is one of the world's best.

Now, Sutton has taken a close look at Wednesday's Real Madrid vs. Manchester City match from all sides and locked in his best bets. You ABSOLUTELY need to see his picks and analysis before making any selections of your own.

Who wins Manchester City vs. Real Madrid on Wednesday? And where does all the betting value lie? ... Join SportsLine now to see Brandt Sutton's best bets for Real Madrid vs. Manchester City, all from the insider who is 72-56 in his last 128 soccer picks!