The Detroit Tigers look to complete the three-game series sweep when they battle the Tampa Bay Rays in a key American League matchup on Wednesday. The Rays (49-43), who are third in the American League East, are 21-18 on the road this season. The Tigers (59-34), first in the AL Central, are 32-14 on their home field in 2025.

First pitch from Comerica Park in Detroit is set for 5:10 p.m. ET. The Tigers have won seven of the last 10 meetings with the Rays. Detroitis a -150 favorite on the money line (risk $150 to win $100) in the latest Rays vs. Tigers odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 8 in the latest MLB odds. 

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