In an AFC divisional playoff rematch from this past January, the Baltimore Ravens and Buffalo Bills clash in a season-opening matchup on Sunday Night Football. Buffalo earned a 27-25 win in their Jan. 19 playoff. The Ravens (12-5 in 2024), who won the AFC North, were 6-3 on the road last year. The Bills (13-4 in 2024), who won the AFC East, were 8-0 on their home field during the regular season. Both teams had 10 against the spread victories in the 2024 regular season.

Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 8:20 p.m. ET. The Ravens lead the all-time series 7-6, including a 7-4 edge in the regular season. Baltimore is a 1.5-point favorite in the latest Ravens vs. Bills odds, after the Bills opened as favorites of 1.5 points. The over/under for total points scored is 50.5, making it the highest of NFL Week 1. Baltimore is at -125 on the money line (risk $125 to win $100), while Buffalo is the +105 underdog (risk $100 to win $105).

Before making any Ravens vs. Bills picks or NFL predictions, you NEED to hear what SportsLine football expert Mike Tierney has to say.

A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney is 235-189-13 in the NFL the past three seasons, returning $2,505 to $100 players (every bet 1 unit). He hit 61.2 percent of his ATS picks (61-39-3) last season. He is also 45-22-1 (+2047) on his last 68 picks involving Baltimore Ravens games. Anyone who has followed him could be WAY up!

Now, Tierney has analyzed Ravens vs. Bills from every angle and just locked in his picks and predictions.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Ravens vs. Bills on Sunday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Ravens vs. Bills spread to jump on, all from the football expert who was 61-39-3 last season on his NFL picks!