Ravens vs. Bills line, odds: Proven model releases spread pick for 2025 NFL Week 1 Sunday Night Football

The Buffalo Bills will host fellow AFC juggernauts the Baltimore Ravens on Sunday Night Football on Sept. 7. Both teams topped their respective divisions last season, with Buffalo finishing 13-4 and Baltimore compiling a 12-5 record. This 2025 NFL Week 1 matchup is a rematch of last season's tense AFC Divisional Round standoff, which the Bills won 27-25, which followed the Ravens defeating the Bills in a Week 4 contest. Buffalo was 4-1 against the spread in primetime games last season, with the one defeat coming to Baltimore.

Kickoff from Highmark Stadium in Buffalo is set for 8:20 p.m. ET. Baltimore is a 1.5-point favorite in the latest Ravens vs. Bills odds, after Buffalo originally opened as 1.5-point favorites. The over/under for total points scored is 50.5, making it the highest of Week 1. Baltimore is at -125 on the money line (risk $125 to win $100), while Buffalo is at +105 (risk $100 to win $105). Before making any Bills vs. Ravens picks or 2025 NFL Week 1 predictions of your own, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model went 31-15 on top-rated picks in 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Bills vs. Ravens on Sunday Night Football.

We can tell you it's leaning Over the point total, but also says that one side of the spread hits in well over 50% of simulations! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Bills vs. Ravens in NFL Week 1? ... Join SportsLine RIGHT NOW to see which side of the Ravens vs. Bills line to back, all from the model that went 31-15 on top-rated picks in 2024!