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Rangers vs. Yankees odds, line, start time, picks, best bets for May 22 matchup from proven model

SportsLine's projection model, which is on a 13-8 roll on top-rated MLB picks, has locked in its MLB picks for the Rangers vs. Yankees on Wednesday

ByUpdated: May 22, 2025 1:19PM UTC . 2 min read

The New York Yankees look to complete the three-game sweep over the Texas Rangers when they meet on Thursday afternoon. The Rangers (25-25), who have lost three in a row, are 8-15 on the road this season. The Yankees (29-19), who have won three straight, are 17-9 on their home field in 2025.

First pitch from Yankee Stadium in New York is set for 12:35 p.m. ET. New York is a -159 favorite on the money line (risk $159 to win $100) in the latest Rangers vs. Yankees odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 7 in the latest MLB odds. 

Before you make any Rangers vs. Yankees picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 9 of the 2025 MLB season on a 13-8 run (62%) on top-rated MLB money-line picks. Anybody following could have seen strong returns!

The model has simulated Rangers vs. Yankees 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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Daniel Kohn

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