Rams vs. 49ers prediction, line, odds: Proven model releases spread pick for 2025 NFL Week 5 Thursday Night Football
The SportsLine projection model, which is 39-20 on top-rated picks since last season, reveals 49ers vs. Rams picks for Thursday Night Football in NFL Week 5
An NFC West battle takes place on 'Thursday Night Football' in Week 5 as the Los Angeles Rams host the San Francisco 49ers. Both teams are 3-1, with San Fran coming off its first defeat as it was upset, 26-21, by the Jacksonville Jaguars on Sunday. Meanwhile, the Rams bounced back from a Week 3 defeat by knocking off the previously unbeaten Indianapolis Colts, 27-20, in Week 4. The Rams have won the last three matchups with the Niners. Brock Purdy (toe) is among the 49ers players who have been ruled out as have receivers Jauan Jennings and Ricky Pearsall.
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Kickoff is at 8:15 p.m. ET from SoFi Stadium in Inglewood, Calif. The latest Rams vs. 49ers odds have Los Angeles as the 8.5-point favorites, after opening as 1.5-point favorites. The over/under for total points is 43.5, after opening at 47.5. L.A. is a -465 favorite on the money line (risk $465 to win $100), while San Francisco is priced at +358 (risk $100 to win $358).
Before making any 49ers vs. Rams picks or Thursday Night Football predictions, you NEED to see which side the proven SportsLine projection model is on.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has locked in another confident pick for Rams vs. 49ers on Thursday Night Football.
We can tell you the model is going Over the point total, but also says one side of the spread hits over 50% of the time! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.
So who wins 49ers vs. Rams in NFL Week 5, and which side of the spread hits over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the Rams vs. 49ers line to back, all from the model that is 39-20 on top-rated picks since 2024!
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