Rams vs. 49ers odds, line, spread: Proven model reveals NFL picks, predictions for Week 8, 2022

An NFC West battle is on tap between the Los Angeles Rams and the San Francisco 49ers at 4:25 p.m. ET on Sunday at SoFi Stadium. Los Angeles snapped its two-game losing streak with a 24-10 win over Carolina in its last game, but it has not had much success against the 49ers in recent seasons. This game is listed as pick'em in the latest Rams vs. 49ers odds from Caesars Sportsbook, while the over/under is set at 42. 

Before you make any 49ers vs. Rams picks or predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 8 of the 2022 NFL season on an incredible 148-107 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has simulated Rams vs. 49ers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Rams vs. 49ers? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.