Queens vs. Winthrop odds, prediction: 2025 NCAA Field of 68 Opening Day Marathon picks from proven model

A pair of 20-win teams from a year ago will tip off the 2025-26 season when the Queens Royals take on the Winthrop Eagles in the Field of 68 Opening Day Marathon on Monday morning. Queens closed out its exhibition season with a 103-67 win over Johnson C. Smith, while Winthrop topped Georgia Southern 96-91 on Oct. 25. The Royals finished 20-15 overall and placed sixth at 11-7 in the Atlantic Sun Conference in 2024-25. The Eagles were 23-11 overall and second in the Big South at 11-5.

Tip-off from the Rock Hill Sports & Events Center in Rock Hill, S.C., is set for 8 a.m. ET. Winthrop leads the all-time series 5-2, including an 86-78 win last year. Winthrop is a 4.5-point favorite in the latest Queens vs. Winthrop odds from SportsLine consensus, while the over/under for total points scored is 163.5.

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Before making any Queens vs. Winthrop picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It finished last season on a 229-169 roll (+1805) on all top-rated college basketball picks dating back to 2023.  This model also ranks in the 99.5th percentile in a major bracket contest after correctly calling every Elite Eight and Final Four team last year. Anyone following could have seen HUGE returns!

The model has simulated Queens vs. Winthrop 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits over 60% of the time!

So who wins Queens vs. Winthrop, and which side of the spread hits over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that was above the 99th percentile in bracket picks!

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