Purdue vs. Queens odds, prediction: 2026 NCAA Tournament picks from proven model

The fifteen-seeded Queens University Royals will battle the second-seeded Purdue Boilermakers in a first-round matchup in the West regional of the NCAA Tournament on Friday. Queens University (21-13) won the Atlantic Sun tournament in overtime over Central Arkansas, 98-93. Purdue (27-8) won the 2026 Big Ten Conference tournament, beating Michigan 80-72 in the final to win their third conference tournament title and first since 2023. The Boilermakers will enter the NCAA Tournament with a top-two seed for the third time in four years, while this is the Royals' first-ever NCAA Tournament appearance. 

Tipoff from the Enterprise Center at Aztec Bowl in Saint Louis, Missouri, is set for 6:35 p.m. ET. This will be the first-ever matcup between the two schools. Purdue is a 25.5-point favorite in the latest Purdue vs Queens odds from DraftKings Sportsbook, while the over/under for total points scored is 163.5. 

Before making any Queens vs. Purdue picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Purdue vs Queens 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits almost 60% of the time!

So who wins Purdue vs Queens, and which side of the spread hits almost 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!