Purdue vs. Nebraska odds, prediction: 2026 Big Ten Conference men's college basketball picks from proven model

The 12th-ranked Purdue Boilermakers battle the ninth-ranked Nebraska Cornhuskers in a key Big Ten Conference matchup on Tuesday night. Purdue is coming off a 68-64 win over Oregon on Saturday, while Nebraska defeated Rutgers 80-68 that same day. The Boilermakers (19-4), who are 3-2 against ranked opponents this season, are 5-2 on the road. The Cornhuskers (21-2), who are 2-2 against ranked foes, are 12-1 on their home court.

Tip-off from Pinnacle Bank Arena in Lincoln, Neb., is set for 7 p.m. ET. Purdue leads the all-time series 21-7. Nebraska is a 2.5-point favorite in the latest Purdue vs. Nebraska odds from DraftKings Sportsbook, while the over/under for total points scored is 147.5.

Before making any Purdue vs. Nebraska picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 15 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 11-5 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Purdue vs. Nebraska 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits over 50% of the time!

So who wins Purdue vs. Nebraska, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!