Purdue vs. Iowa odds, prediction: 2026 men's college basketball picks for Jan. 14 from proven model

A Big Ten battle will help get the Wednesday college basketball schedule underway when the Purdue Boilermakers host the Iowa Hawkeyes. No. 5 Purdue is 15-1 and 5-0 in the Big Ten, while Iowa is 12-4 and 2-3 in the Big Ten.

Tipoff is at 6:30 p.m. ET from Mackey Arena. The Boilermakers are 10.5-point favorites per the latest Purdue vs. Iowa odds, while the over/under for total points is 142.5.

Before making any Iowa vs. Purdue picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and enters Week 11 on a sizzling 9-1 run on top-ranked over/under picks dating back to last year. Anyone following could have seen HUGE returns!

The model has simulated Iowa vs. Purdue 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in nearly 60% of simulations!

So who wins Purdue vs. Iowa, and which side hits in nearly 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!