Purdue vs. Illinois odds, prediction: 2026 college basketball picks for Jan. 24 from proven model

The Purdue Boilermakers host the Illinois Fighting Illini in Big Ten action on Saturday afternoon. Purdue is 17-2 overall and 7-1 in the Big Ten, while Illinois is 16-3 and also 7-1 in conference play. 

Tipoff from Mackey Arena is at 3 p.m. ET. Purdue is a 5.5-point favorite in the latest Purdue vs. Illinois odds, while the over/under is 152.5.

Before making any Illinois vs. Purdue picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 12 on a sizzling 10-1 run on top-ranked over/under picks. Anyone following could have seen HUGE returns!

The model has simulated Purdue vs. Illinois 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Purdue vs. Illinois, and which side hits in over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!