Purdue vs. Arizona odds, prediction: 2026 NCAA Tournament picks from proven model

A spot in the Final Four is on the line when the second-seeded Purdue Boilermakers battle the one-seeded Arizona Wildcats in an NCAA Tournament West Region Elite 8 matchup on Saturday. Purdue is coming off a 79-77 win over an 11-seeded Texas on Thursday in the Sweet 16, while Arizona defeated fourth-seeded Arkansas 109-88. The Boilermakers (30-8), who placed sixth in the Big Ten at 13-7, have won seven in a row. The Wildcats (35-2), who finished first in the Big 12 at 16-2, have won 12 straight games. 

Tipoff from the SAP Center at San Jose is set for 8:49 p.m. ET. Purdue leads the all-time men's basketball series against Arizona 8-5, having won the last three meetings. Arizona is a 6.5-point favorite in the latest Purdue vs. Arizona odds, while the over/under for total points scored is 153.5. 

Before making any Arizona vs. Purdue picks, you NEED to see the basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 Sweet 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Purdue vs. Arizona 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Purdue vs. Arizona, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!