Prairie View A&M vs. Florida odds, prediction: 2026 NCAA Tournament picks from proven model

The 16th-seeded Prairie View A&M Panthers battle the top-seeded Florida Gators in the first round of the NCAA Tournament South Region on Friday. Prairie View is coming off a 67-55 win over Lehigh in Wednesday's First Four matchup, while Florida dropped a 91-74 decision to Vanderbilt in the semifinals of the Southeastern Conference Tournament on Saturday. The Panthers (19-17), who have won eight in a row, finished eighth in the Southwestern Athletic Conference standings at 9-9. The Gators (26-7), who have won 12 of their last 13, won the SEC regular-season title with a 16-2 conference mark.

Tip-off from Benchmark International Arena in Tampa, Fla., is set for 9:25 p.m. ET. Florida leads the all-time series 1-0, posting a 94-33 win in 2006. Florida is a 35.5-point favorite in the latest Prairie View A&M vs. Florida odds from DraftKings Sportsbook, while the over/under for total points scored is 155.5. 

Before making any Prairie View A&M vs. Florida picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Prairie View A&M vs. Florida 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits in nearly 60% of simulations!

So who wins Prairie View A&M vs. Florida, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!