We've got another exciting Eastern Conference matchup on Wednesday's NBA schedule as the Boston Celtics and the Detroit Pistons are set to tip at 7:30 p.m. ET at TD Garden. Boston is 17-4 overall and 8-2 at home, while Detroit is 9-14 overall and 5-7 on the road. The Celtics are favored by 13.5 points in the latest Celtics vs. Pistons odds via SportsLine consensus, and the over/under is 221.5 points.

Before entering any Celtics vs. Pistons picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 7 of the 2024-25 NBA season on a sizzling 116-80 roll on all top-rated NBA picks dating back to last season, returning nearly $3,000. Anyone following at sportsbooks and on betting apps has seen huge returns.

The model has simulated Celtics vs. Pistons 10,000 times and the results are in. We can tell you that the model is leaning Over the total, and it's also generated a point-spread pick that hits in well over 60% of simulations. 

So who wins Celtics vs. Pistons? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks.