Pirates vs. Cubs odds, lines: Proven model reveals MLB picks, predictions for Sept. 3, 2021, matchup

The Pittsburgh Pirates will look to even their series with the Chicago Cubs when the teams meet in Game 2 of the four-game series on Friday afternoon. The Cubs defeated the Pirates 6-5 in 11 innings on Thursday. First pitch from Wrigley Field in Chicago is set for 2:20 p.m. ET.

The Cubs are listed as -135 favorites (risk $135 to win $100) on the money line in the latest Pirates vs. Cubs odds from Caesars Sportsbook, while the over-under for total runs scored is nine (see the latest lines for every game on our MLB odds page).

Before making any Pirates vs. Cubs picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, is 176-142 on top-rated MLB money-line picks through 22 weeks in the 2021 season, returning almost $1,000. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some HUGE returns!

Now, it has set its sights on Pirates vs. Cubs. We can tell you the model is projecting 8.8 total runs, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Pirates vs. Cubs? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the Pirates vs. Cubs money line you should be all over on Friday, all from the model that is 176-142 on top-rated MLB money-line picks in 2021!