Pirates vs. Brewers odds, line, start time, picks, best bets for June 25 National League Central matchup from proven model

Two of Major League Baseball's top young pitching prospects square off when the Pittsburgh Pirates battle the Milwaukee Brewers on Wednesday afternoon. Pittsburgh will send right-hander Paul Skenes (4-6, 1.85 ERA) to the mound, while Milwaukee counters with right-hander Jacob Misiorowski (2-0, 1.64 ERA). The Pirates (32-49), who had a two-game winning streak snapped on Tuesday, are 12-28 on the road this season. The Brewers (44-36), who have won five of six, are 24-16 on their home field in 2025.

First pitch from American Family Field in Milwaukee is set for 2:10 p.m. ET. The Brewers have won six of the last 10 meetings. Pittsburgh is a -111 favorite on the money line (risk $111 to win $100) in the latest Pirates vs. Brewers odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 6.5 in the latest MLB odds. 

Before you make any Pirates vs. Brewers picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 14 of the 2025 MLB season on a profitable 41-32 run on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 22 units of profit. Anybody following could have seen strong returns!

The model has simulated Pirates vs. Brewers 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

Who wins Pirates vs. Brewers, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 41-32 roll on top-rated MLB picks!