Penn State vs. UCLA odds, line: 2025 college football picks for Week 6 predictions from proven model

The No. 7 Penn State Nittany Lions (3-1) travel to play the UCLA Bruins (0-4) in a Big Ten collision on Saturday afternoon. Last weekend, the Nittany Lions fell at home 30-24 to Oregon. Meanwhile, UCLA has dropped three straight games, with a 17-14 loss to Northwestern on Sept. 27. 

Kickoff from Rose Bowl in Pasadena, CA, is at 3:30 p.m. ET on Paramount+. UCLA leads the all-time series 4-3 over Penn State. The Nittany Lions are 24.5-point favorites in the latest Penn State vs. UCLA odds, while the over/under for total points scored is 48.5 via SportsLine consensus. 

Before making any Penn State vs. UCLA picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 37-24 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated Penn State vs. UCLA 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Penn State vs. UCLA, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!