Penn State vs. Northwestern odds, line, spread: Proven model reveals college basketball picks, predictions for Feb. 25, 2022

A Big Ten battle is on tap between the Penn State Nittany Lions and the Northwestern Wildcats at 7 p.m. ET on Friday at the Bryce Jordan Center. Penn State is 11-13 overall and 9-4 at home, while Northwestern is 13-13 overall and 3-6 on the road. The Nittany Lions are favored by 1.5 points in the latest Penn State vs. Northwestern odds from Caesars Sportsbook, and the over-under is set at 129. Before you make any Northwestern vs. Penn State picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Penn State vs. Northwestern 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Penn State vs. Northwestern? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!