Penn State vs. Michigan State odds, line: 2025 college football picks for Week 12 predictions from proven model

A Big Ten battle sees a pair of 3-6 teams matching up on Saturday as the Penn State Nittany Lions visit the Michigan State Spartans. Both squads are also 0-6 in the conference, as they and Purdue are the only winless Big Ten teams in conference play. Penn State lost to Indiana on Saturday by a score of 27-24, while Michigan State is coming off a bye but fell to Minnesota, 23-20, in overtime on Nov. 1.

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month at SportsLine for $1 JOIN NOW. 

Kickoff from Spartan Stadium in East Lansing, Mich., is at 3:30 p.m. ET on CBS and Paramount+, where you can get a free 7-day trial. Penn State won the last matchup, 42-0, back in 2023. 

The Nittany Lions are 7-point favorites in the latest Michigan State vs. Penn State odds, while the over/under for total points scored is 49.5 via SportsLine consensus. 

Before making any Penn State vs. Michigan State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anyone following could have seen impressive returns.

The model has simulated Michigan State vs. Penn State 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 60% of simulations.

So who wins Penn State vs. Michigan State, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the Michigan State vs. Penn State spread you need to jump on, all from the computer model that has crushed its college football picks!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month at SportsLine for $1 JOIN NOW.