Penn State vs. Clemson odds, line: 2025 college football picks for Pinstripe Bowl matchup from proven model

The Penn State Nittany Lions will take on the Clemson Tigers in the Pinstripe Bowl on Saturday, Dec. 27. Both rosters have been hit hard by the transfer portal. The Nittany Lions (6-6), who finished tied for 12th in the Big Ten Conference at 3-6, finished the season on a three-game winning streak. The Tigers (7-5), who tied for seventh in the Atlantic Coast Conference at 4-4, finished the regular season with four wins in a row.

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Both teams will be without multiple players due to injury or the transfer portal. The Nittany Lions could be without as many as 12 players. Running back Nicholas Singleton, the team's second-leading rusher has opted out of the game, but leading rusher Kaytron Allen is preparing to play. As for Clemson, leading wide receiver Antonio Williams has declared for the NFL Draft and has opted out. A good portion of the Tigers' defense has also either entered the transfer portal or opted out for the draft.

Kickoff from Yankee Stadium in New York is at noon ET. Clemson leads the all-time series 1-0, with the Tigers posting a 35-10 win in 1987. The Tigers are 3.5-point favorites in the latest Penn State vs. Clemson odds, while the over/under for total points scored is 48.5 via SportsLine consensus. 

Before making any Penn State vs. Clemson picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

The model has simulated Penn State vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Penn State vs. Clemson, and which side of the spread hits in well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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