Teams looking to turn their fortunes around will clash when the Arizona Cardinals host the New England Patriots on Monday Night Football. Both teams have lost two games in a row and find themselves on the outside of the NFL playoff picture. The game from State Farm Stadium will kick off at 8:15 p.m. ET. New England is favored by 2.5 points in the latest Patriots vs. Cardinals odds at Caesars Sportsbook, while the over/under is 44. Before making any Patriots vs. Cardinals picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 14 of the 2022 NFL season on an incredible 156-112 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model knows wide receiver Jakobi Meyers is New England quarterback Mac Jones' top target. Meyers has 50 receptions for 593 yards (11.9 average) and three touchdowns. He has three explosive plays of 20 yards or more, including a 30-yarder. Meyers has 167 yards after the catch and has converted 28 first downs.

The model also knows Arizona has a dual-threat quarterback in Kyler Murray, who leads the team in passing, completing 258 of 389 attempts (66.3%) for 2,359 yards and 14 touchdowns. He has seven interceptions and an 87.1 rating. Murray is also the team's second-leading rusher, carrying 66 times for 415 yards (6.3 average) and three TDs.

Now, the model has set its sights on Patriots vs. Cardinals on Monday Night Football. We can tell you the model is leaning Under the total, and it also says one side of the spread cashes in more than 50% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Patriots vs. Cardinals on Monday Night Football? And which side of the spread cashes over 50% of the time? ... Join SportsLine right now to find out which side of the Patriots vs. Cardinals spread you should be all over, all from the model on a 156-112 roll on NFL picks!