The Buffalo Bills look to stay unbeaten and take control of the AFC East when they take on the New England Patriots on Sunday Night Football. Buffalo is coming off a 31-19 win over the New Orleans Saints, while New England rolled to a 42-13 win over the Carolina Panthers in Week 4. The Patriots (2-2), who are 1-0 within the division, are also 1-0 on the road in 2025. The Bills (4-0), who are 2-0 in the division, are 3-0 on their home field and enter Sunday Night Football as the last undefeated team left standing.

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Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 8:20 p.m. ET. The Patriots lead the all-time series 79-51-1, but the Bills have won eight of the past 11 meetings, including four straight at home. Buffalo is a 7.5-point favorite in the latest Patriots vs. Bills odds from SportsLine consensus. The over/under for total points scored is 49.5, making it the highest of Week 5. Buffalo is a -429 favorite on the money line (risk $429 to win $100), with New England at +334 (risk $100 to win $334).

Before making any Patriots vs. Bills picks or NFL predictions, you NEED to hear what SportsLine football expert Mike Tierney has to say.

A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney is 235-189-13 in the NFL the past three seasons, returning $2,505 to $100 players. He hit 61.2% of his ATS picks (61-39-3) last season. He is also 26-14-3 (+1072) on his last 43 picks involving Buffalo Bills games. Anyone who has followed him could be WAY up!

Now, Tierney has analyzed Patriots vs. Bills from every angle and just locked in his picks and predictions.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Patriots vs. Bills on Sunday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Patriots vs. Bills spread to jump on, all from the football expert who was 61-39-3 last season on his NFL picks!

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