AFC East rivals square off in NFL Week 5 Sunday Night Football action as the Buffalo Bills host the New England Patriots. The Bills are one of two undefeated teams remaining in the NFL and are coming off of a 31-19 win against the New Orleans Saints. They host a Patriots side sitting at 2-2 and also coming off of a big victory, 42-13 against the Carolina Panthers. Buffalo has won four straight home games versus New England.

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Kickoff from Highmark Stadium is set for 8:20 p.m. ET. Buffalo is a 7.5-point favorite in the latest Patriots vs. Bills odds, and the over/under for total points scored is 49.5, giving this game the highest total of Week 5. The Bills are -435 favorites on the money line (risk $435 to win $100), while the Patriots are +335 underdogs (risk $100 to win $335).

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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Bills vs. Patriots on Sunday Night Football in NFL Week 5.

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