The Carolina Panthers will take on the Detroit Lions at 1 p.m. ET on Saturday at Bank of America Stadium. The Lions have won six of their last seven games, including a 20-17 win over the Jets last week. Detroit is favored by 2.5 points in the latest Panthers vs. Lions odds from Caesars Sportsbook, while the over/under is set at 43.5. 

Before you make any Lions vs. Panthers picks or predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has simulated Panthers vs. Lions 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Panthers vs. Lions? And which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.