The Philadelphia Phillies will look to continue their recent dominance over the San Diego Padres when they meet in the first of a three-game series on Monday. The Padres (45-38), who have lost two of three, are 20-24 on the road this season. The Phillies (49-35), who have won two of three, are 26-14 on their home field in 2025.

First pitch from Citizens Bank Park in Philadelphia is set for 6:30 p.m. ET. The Phillies have won six of the last seven meetings with the Padres. Philadelphia is a -226 favorite on the money line (risk $226 to win $100) in the latest Padres vs. Phillies odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 9 in the latest MLB odds. 

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