Packers vs. Lions line, odds: Proven model releases spread pick for 2025 NFL Week 13 matchup on Thanksgiving Day

The Green Bay Packers and Detroit Lions clash in a key NFC North Division matchup on Thanksgiving Day. Green Bay is coming off a 23-6 win over the Minnesota Vikings, while Detroit rallied for a 34-27 triumph over the New York Giants on Sunday. The Packers (7-3-1), who have won two in a row, are second in the NFC North, one-half game behind Chicago. The Lions (7-4), who have won two of their last three, are third in the division, one game behind the Bears. Josh Jacobs (knee) has a chance to return for Green Bay after getting three practice sessions in this week. Lions OL Penei Sewell (ankle) is listed as questionable.

Kickoff from Ford Field in Detroit is set for 1 p.m. ET. The Packers lead the all-time series 107-78-7, including a 27-13 win in the season opener at Green Bay. The Lions are 3-point favorites in the latest Packers vs. Lions odds, while the over/under for total points scored is 48.5. Detroit is at -152 on the money line (risk $152 to win$100). Detroit is at -161 on the money line (risk $161 to win$100), with Green Bay at +135 (risk $100 to win $135)

Before making any Packers vs. Lions picks, or 2025 NFL Week 13 predictions of your own, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 13 on a 49-33 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Packers vs. Lions on Thanksgiving Day.

We can tell you it's leaning Over the point total, but also says that one side of the spread hits well over 50% of the time! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Packers vs. Lions in NFL Week 13, and which side of the spread hits well over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the Packers vs. Lions line to back, all from the model that has gone 49-33 on top-rated picks since 2024!

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