Pacers vs. Celtics odds, line: Proven model reveals picks for NBA matchup on Wednesday, January 21

The Boston Celtics look to secure the season series when they battle the Indiana Pacers in an NBA Eastern Conference matchup on Wednesday night. Indiana is coming off a 113-104 loss at Philadelphia on Monday, while Boston dropped a 104-103 decision at Detroit that same day. The Pacers (10-34), who are fifth in the Central Division, are just 2-18 on the road this season. The Celtics (26-16), who lead the Atlantic Division, are 12-7 on their home floor. Indiana will be without Benedict Mathurin (thumb).

Tip-off from TD Garden in Boston is set for 7:30 p.m. ET. The Celtics lead the all-time series 112-88, and have won two of the three previous meetings this season. Boston is a 10.5-point favorite in the latest Pacers vs. Celtics odds from DraftKings Sportsbook, while the over/under for total points scored is 226.5. Before making any Pacers vs. Celtics picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 14 of the 2025-26 NBA season on a sizzling 35-15 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Pacers vs. Celtics 10,000 times and the results are in. We can tell you that the model is going Over on the point total, and it also says one side of the spread hits in well over 60% of simulations!

Who wins Pacers vs. Celtics, and which side of the spread hits well over 60% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 35-15 roll on top-rated NBA picks!