Orioles vs. Phillies odds, line, start time, picks, best bets for August 6 matchup from proven model

The Philadelphia Phillies go for the three-game series sweep when they meet the Baltimore Orioles in a key interleague series on Wednesday afternoon. The Orioles (51-63), who have lost three in a row, are 24-36 on the road this season. The Phillies (65-48), who are on a three-game winning streak, are 37-20 on their home field in 2025.

First pitch from Citizens Bank Park in Philadelphia is set for 12:35 p.m. ET. The Phillies have won seven of the last 10 meetings with the Orioles. Philadelphia is a -161 favorite on the money line (risk $161 to win $100) in the latest Orioles vs. Phillies odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 8.5 in the latest MLB odds. 

Before you make any Orioles vs. Phillies picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 20 of the 2025 MLB season a profitable 28-23 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning nearly 60 units of profit. Anybody following could have seen strong returns!

The model has simulated Orioles vs. Phillies 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

Who wins Orioles vs. Phillies, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 28-23 roll on top-rated MLB money-line picks!