loading...
League Logo
NFL
League Logo
NFL
League Logo
CFB
League Logo
NBA
League Logo
CBB
League Logo
NHL
All
  • Loading...
loading...

Orioles vs. Phillies odds, line, start time, picks, best bets for August 6 matchup from proven model

SportsLine's projection model, which is on a 28-23 roll on top-rated MLB money-line picks, has locked in its MLB picks for the Baltimore vs. Philadelphia matchup on Wednesday

ByPublished: Aug 06, 2025 1:40AM UTC . 2 min read

The Philadelphia Phillies go for the three-game series sweep when they meet the Baltimore Orioles in a key interleague series on Wednesday afternoon. The Orioles (51-63), who have lost three in a row, are 24-36 on the road this season. The Phillies (65-48), who are on a three-game winning streak, are 37-20 on their home field in 2025.

First pitch from Citizens Bank Park in Philadelphia is set for 12:35 p.m. ET. The Phillies have won seven of the last 10 meetings with the Orioles. Philadelphia is a -161 favorite on the money line (risk $161 to win $100) in the latest Orioles vs. Phillies odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 8.5 in the latest MLB odds. 

Before you make any Orioles vs. Phillies picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 20 of the 2025 MLB season a profitable 28-23 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning nearly 60 units of profit. Anybody following could have seen strong returns!

The model has simulated Orioles vs. Phillies 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!

JOIN NOW
Avatar
Daniel Kohn
Share This Story
© 2025 CBS INTERACTIVE INC. ALL RIGHTS RESERVED. SportsLine and SportsLine PRO are registered trademarks of SportsLine.com, Inc.FANS ONLY
In partnership with...247 Sports

FOLLOW US:

The content on this site is for entertainment purposes only and SportsLine makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event. There is no gambling offered on this site. This site contains commercial content and SportsLine may be compensated for the links provided on this site.