Orioles vs. Guardians odds, line, start time, picks, best bets for Thursday, July 24, matchup from proven model

The Cleveland Guardians will look for the four-game series sweep when they take on the Baltimore Orioles in a key American League matchup on Thursday afternoon. Cleveland is coming off a 3-2 win on Wednesday. The Orioles (44-57), who are fifth in the AL East, are 22-32 on the road this season. The Guardians (51-50), who are second in the AL Central, are 25-24 on their home field in 2025.

First pitch from Progressive Field in Cleveland is set for 1:10 p.m. ET. The Guardians have won five of the last seven meetings with the Orioles in games played in Cleveland, including three in a row. Cleveland is a -115 favorite on the money line (risk $115 to win $100) in the latest Orioles vs. Guardians odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 9 in the latest MLB odds.  

Before you make any Orioles vs. Guardians picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 17 of the 2025 MLB season 46-43 on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 40 units of profit. Anybody following could have seen strong returns!

The model has simulated Orioles vs. Guardians 10,000 times and the results are in. We can tell you the model is going Under on the run total, and it also says one side of the money line has all the value!

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