Oregon vs. USC odds, line: 2023 college football picks, Week 11 predictions from proven model

The No. 6 Oregon Ducks will try to move another game closer to the Pac-12 title game when they host the USC Trojans on Saturday night. Oregon is riding a three-game winning streak, including a 63-19 win over California last week. USC is hoping to get back on track after losing three of its last four games to fall out of the top 25. 

Kickoff is set for 10:30 p.m. ET on Saturday at Autzen Stadium in Eugene. Oregon is favored by 15 points in the latest Oregon vs. USC odds, while the over/under is set at 75 points, per SportsLine consensus. 

Before entering any USC vs. Oregon picks, you NEED to see the college football predictions from the model at SportsLine.

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The model has simulated Oregon vs. USC 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

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