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Oregon vs. Penn State line, odds: Proven model releases spread pick for 2025 college football Week 5 matchup

The SportsLine projection model, which is a combined 35-22 on money-line and over/under picks since the beginning of 2024, reveals its Big Ten picks for Oregon Ducks vs. Penn State Nittany Lions in college football Week 5

ByPublished: Sep 27, 2025 5:10PM UTC . 2 min read

The No. 6 Oregon Ducks (4-0) visit the No. 3 Penn State Nittany Lions (3-0) in a college football Week 5 showdown. The hosts will be fresh off of their early-season bye week and playing their first conference opponent after shutting down Nevada, FIU and Villanova to start off the season. They host an undefeated Ducks side that already has one win this season against a Big Ten opponent, defeating Northwestern 34-14 in Week 2.

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Kickoff from Beaver Stadium is set for 7:30 p.m. ET. The Nittany Lions are 3.5-point favorites in the latest Oregon vs. Penn State odds, and the over/under for total points scored is 53.5. Penn State is a -174 money-line favorite (risk $174 to win $100) and Oregon is a +145 underdog (risk $100 to win $145). 

Before making any Penn State vs. Oregon picks, you NEED to see which side the proven SportsLine projection model is on. 

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 35-22 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

Now, the model has locked in another confident pick for Oregon vs. Penn State in college football Week 5.

We can tell you it's leaning Over the point total, but also says that one side of the spread hits well over 50% of the time! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Penn State vs. Oregon in College Football Week 5, and which side of the spread hits well over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the Oregon vs. Penn State line to back, all from the model that has gone a combined 35-22 on top-rated picks since 2024!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW. 

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Chelena Goldman

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