The fourth and final matchup of the first round of the 2025-26 College Football Playoff first round unfolds on Saturday night when the No. 5 Oregon Ducks host the No. 12 James Madison Dukes. James Madison squeezed in the field as the fifth highest-ranked conference champion after winning the Sun Belt. Oregon claimed the top at-large spot after an 11-1 campaign.
Kickoff is at 7:30 p.m. ET from Autzen Stadium. The Ducks are 20.5-point favorites in the latest Oregon vs. James Madison odds, while the over/under is 45.5.
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