Oregon vs. James Madison prediction, odds, time: 2025 College Football Playoff picks from proven model

The fourth and final matchup of the first round of the 2025-26 College Football Playoff first round unfolds on Saturday night when the No. 5 Oregon Ducks host the No. 12 James Madison Dukes. James Madison squeezed in the field as the fifth highest-ranked conference champion after winning the Sun Belt. Oregon claimed the top at-large spot after an 11-1 campaign.

Kickoff is at 7:30 p.m. ET from Autzen Stadium. The Ducks are 21.5-point favorites in the latest Oregon vs. James Madison odds, while the over/under is 49.5.

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Before making any James Madison vs. Oregon picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

The model has simulated Oregon vs. James Madison 10,000 times and the results are in. We can tell you that the model is going Over, and it also says one side of the spread hits 60% of the time!

So who wins Oregon vs. James Madison, and which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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