The Ole Miss Rebels will take on the Troy Trojans at 4 p.m. ET on Saturday at Vaught-Hemingway Stadium at Hollingsworth Field. Ole Miss picked up a 51-21 win during the lone prior meeting between these teams, which came in 2013. The Rebels are favored by 21.5 points in the latest Ole Miss vs. Troy odds from Caesars Sportsbook, while the over/under is set at 57. 

Before you make any Troy vs. Ole Miss picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football side picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated Ole Miss vs. Troy 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 70% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Ole Miss vs. Troy? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!