Ole Miss vs. Oklahoma odds, line: 2025 college football picks for Week 9 predictions from proven model

The No. 8 Ole Miss Rebels (6-1) and the No. 13 Oklahoma Sooners (6-1) play in an SEC tilt on Saturday. The Rebels went on the road last week and fell 43-35 to Georgia. The Sooners bounced back from a loss and beat South Carolina 26-7 in Week 8. 

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Kickoff from the Gaylord Family-Oklahoma Memorial Stadium in Norman, Oklahoma, is at noon ET. The Sooners are 4.5-point favorites in the latest Ole Miss vs. Oklahoma odds, while the over/under for total points scored is 52.5 via SportsLine consensus. 

Before making any Ole Miss vs. Oklahoma picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 42-30 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated Ole Miss vs. Oklahoma 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in nearly 70% of simulations!

So who wins Ole Miss vs. Oklahoma, and which side of the spread hits nearly 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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