Oklahoma vs. Missouri odds, line: 2025 college football picks for Week 13 predictions from proven model

A top-25 SEC matchup on Saturday has the No. 8 Oklahoma Sooners hosting the No. 23 Missouri Tigers. Oklahoma (8-2, 4-2 SEC) is coming off a 23-21 upset of then-No. 4 Alabama on Saturday, which came a week after knocking off a higher-ranked Tennessee squad. Mizzou (7-3, 3-3 SEC) ended a two-game losing streak in Week 12 by defeating Mississippi State 49-27. Missouri won the first SEC game between the two last year, 30-23, at home. Mizzou quarterback Beau Pribula (ankle) has been cleared to return.

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Kickoff is at noon ET from Memorial Stadium in Norman, Okla. The Sooners are 5.5-point favorites in the latest Oklahoma vs. Missouri odds, while the over/under for total points scored is 42.5 via SportsLine consensus. 

Before making any Missouri vs. Oklahoma picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

The model has simulated Oklahoma vs. Missouri 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread is the better value1

So who wins Missouri vs. Oklahoma, and which side of the spread is the better value? Join SportsLine right now to see which side of the Oklahoma vs. Missouri spread you need to jump on, all from the computer model that has crushed its college football picks!

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