Oklahoma vs. Colorado odds, prediction: 2026 College Basketball Crown picks from proven model

A spot in the College Basketball Crown semifinals is on the line when the Oklahoma Sooners take on the Colorado Buffaloes on Saturday. The Sooners (19-15) were the first team left out of the NCAA tournament and lost to Arkansas by three points in the SEC tournament. The Buffaloes (17-15) started the season (12-3) before Big 12 conference play, where Colorado finished (7-12). The Sooners have won seven of their last eight games, while the Buffaloes have lost two of their last three.

Tip-off from the MGM Grand Garden Arena in Paradise, Nevada, is set for 8 p.m. ET. Oklahoma leads the all-time series 88-49. The two teams were longtime conference rivals in the Big Eight and the Big 12 before Colorado moved to the Pac-12 and Oklahoma joined the SEC. Oklahoma is a 9.5-point favorite in the latest Oklahoma vs. Colorado odds, while the over/under for total points scored is 157.5. 

Before making any Colorado vs. Oklahoma picks, you NEED to see the basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 Final Four on a sizzling 11-1 run on its top-rated over/under college basketball picks dating back to last season, and is on a 28-22 run on top-rated CBB side picks. 

The model has simulated Oklahoma vs. Colorado 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits almost 60% of the time!

So who wins Oklahoma vs. Colorado, and which side of the spread hits almost 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!