The 2021 version of the Bedlam Series is on tap between the No. 7 Oklahoma State Cowboys and the No. 10 Oklahoma Sooners at 7:30 p.m. ET on Saturday, Nov. 27 at Boone Pickens Stadium. Both teams are 10-1; Oklahoma State is 6-0 at home, while Oklahoma is 2-1 on the road. 

The Cowboys are favored by four points in the latest Oklahoma State vs. Oklahoma odds from Caesars Sportsbook, and the over-under is set at 49.5. 

Before making any Oklahoma vs. Oklahoma State picks, you'll want to see the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Oklahoma State vs. Oklahoma 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. 

So who wins Oklahoma State vs. Oklahoma? And which side of the spread hits more than 60 percent of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.