Ohio State vs. Purdue odds, prediction: 2026 men's college basketball picks for March 1 from proven model

Longtime Big Ten rivals will meet on Sunday on CBS and Paramount+ (sign up here) when the Purdue Boilermakers visit the Ohio State Buckeyes. No. 8 Purdue (22-6, 12-5 Big Ten) has won five of its last seven but dropped its last contest to Michigan State on Thursday. Ohio State (17-11, 9-8 Big Ten) is coming off back-to-back losses, including a Wednesday loss to Iowa. The Buckeyes have won the last two matchups, each coming by 4 or fewer points.

Tipoff is at 1:30 p.m. ET from the Value City Arena in Columbus, Ohio. The Boilermakers are 6.5-point favorites in the latest Ohio State vs. Purdue odds, while the over/under for total points scored is 150.5. Purdue is at -289 on the money line (risk $289 to win $100), with Ohio State at +231.

Before making any Purdue vs. Ohio State college basketball picks, check out the latest college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Ohio State vs. Purdue 10,000 times and the results are in. The model is going Over, and it also says one side of the spread hits almost 60% of the time!

So who wins Purdue vs. Ohio State, and which side of the spread hits in almost 60% of simulations? Join SportsLine right now to see which side of the Ohio State vs. Purdue spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!