Ohio State vs. Michigan odds, prediction: 2026 Big Ten Conference men's college basketball picks from proven model

The third-ranked Michigan Wolverines will look to win their fourth in a row when they battle the Ohio State Buckeyes in a key Big Ten Conference matchup on Friday. Ohio State is coming off an 82-74 win over Minnesota on Tuesday, while Michigan downed Indiana 86-72 that same night. The Buckeyes (13-5), who are 0-3 against ranked teams this season, are 3-2 on the road this season. The Wolverines (17-1, 7-1 Big Ten), who are 14-1 against unranked opponents, are 8-1 on their home court.

Tip-off from Crisler Center in Ann Arbor, Mich., is set for 8 p.m. ET. Ohio State leads the all-time series 108-84, but Michigan has won four of the last five meetings. Michigan is a 15.5-point favorite in the latest Ohio State vs. Michigan odds from DraftKings Sportsbook, while the over/under for total points scored is 163.5. 

Before making any Ohio State vs. Michigan picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 12 on a sizzling 10-1 run on top-ranked over/under picks. Anyone following could have seen HUGE returns!

The model has simulated Ohio State vs. Michigan 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in nearly 70% of simulations!

So who wins Ohio State vs. Michigan, and which side hits nearly 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!