Nuggets vs. Knicks odds, line: Proven model reveals picks for NBA matchup on Wednesday, February 4

Teams trending in opposite directions meet when the Denver Nuggets face the New York Knicks in a key NBA matchup on Wednesday. Denver lost its second game in a row on Tuesday, falling 124-121 at Detroit, while New York won its seventh in a row with a 132-101 win at Washington. The Nuggets (33-18), who are second in the Northwest Division, are 19-8 on the road this season. The Knicks (32-18), who co-lead the Atlantic Division with Boston, are 20-6 on their home court. 

Ti-off from Madison Square Garden in New York is set for 7 p.m. ET. The Nuggets lead the all-time series 52-49, but the Knicks won the last two meetings. New York is a 5.5-point favorite in the latest Nuggets vs. Knicks odds from DraftKings Sportsbook, while the over/under for total points scored is 226.5. 

Before making any Nuggets vs. Knicks picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 16 of the 2025-26 NBA season on a sizzling 38-16 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Nuggets vs. Knicks 10,000 times and the results are in. We can tell you that the model is going Over on the point total, and it also says one side of the spread hits in nearly 60% of simulations!

Who wins Nuggets vs. Knicks, and which side of the spread hits nearly 60% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 38-16 roll on top-rated NBA picks!