Two of college football's bluebloods collide when the No. 10 USC Trojans and No. 21 Notre Dame Fighting Irish square off on Saturday at Notre Dame Stadium in South Bend, Ind. The Trojans (6-0, 4-0 in Pac-12) are fighting for a spot in the College Football Playoff. Meanwhile the Fighting Irish (5-2) are reeling after losing 33-20 at Louisville on Saturday, which effectively knocked Notre Dame out of CFP consideration.

Kickoff is scheduled for 7:30 p.m. ET. The Fighting Irish are 3-point favorites in the latest Notre Dame vs. USC odds, while the over/under for total points scored is 60.5, down 2 points from the opening line. The Irish are -144 favorites on the money line (See up-to-date odds for every game this week on our college football odds page.)

Before you make any USC vs. Notre Dame picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of more than $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model knows that the Fighting Irish face a USC defense that is struggling again this season. One year after giving up 423.9 yards per game, which ranked 105th in the country, the Trojans are allowing 421.3 yards a game, which is 109th. In last week's 43-41 triple-overtime win over Arizona, USC coughed up 506 total yards to the Wildcats.

The model also has taken into account that reigning Heisman Trophy winner Caleb Williams is building a strong case to win a second consecutive Heisman. The overwhelming favorite to be the No. 1 pick in next year's NFL Draft, Williams leads the country in passing efficiency (206.4), passing touchdowns (22) and points responsible for (172). He also ranks second in yards per pass attempt (10.98).

Now, the model has set its sights on Notre Dame vs. USC. We can tell you it is leaning Over the total, and it also says one side of the spread has all of the value! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins USC vs. Notre Dame? And which side of the spread has all of the value? ... Join SportsLine right now to find out which side of the Notre Dame vs. USC spread you should be all over Saturday, all from the model on a roll on college football picks!