A rivalry is rekindled when the No. 15 Notre Dame Fighting Irish take on the No. 6 USC Trojans at 7:30 p.m. ET on Saturday. USC is favored by 4 points at Caesars Sportsbook, while the over/under is set at 63.5 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Notre Dame vs. USC picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Notre Dame is potent on defense. Opponents are averaging only 20.3 points per game against the Fighting Irish, and Notre Dame is allowing only 317.2 total yards per game. Notre Dame is above-average against the run and the pass, including 33 sacks and opponents generating only 3.8 yards per carry on the ground. 

The model also knows USC is electric on the offensive side. The Trojans are No. 3 in the country in scoring, averaging 42.9 points per game. USC has 40 points or more in nine games this season. USC is also in the top four of the nation in total yards and passing yards, with the Trojans averaging 9.1 yards per pass attempt.

Now, it has set its sights on Notre Dame vs. USC. We can tell you the model is leaning Under the total, and it also says one side of the spread hits in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Notre Dame vs. USC? And which side of the spread hits in well over 50% of simulations? ... Join SportsLine right now to find out which side of the Notre Dame vs. USC spread you should be all over Saturday, all from the model on a roll on college football picks!