The Notre Dame Fighting Irish will take on the No. 20 Michigan State Spartans at 9:15 p.m. ET on Wednesday at Purcell Pavilion at the Joyce Center. Notre Dame is looking to bounce back from its first loss of the season, which came in a 63-51 setback at St. Bonaventure last Friday. The Spartans are favored by 2.5 points in the latest Notre Dame vs. Michigan State odds from Caesars Sportsbook, while the over/under is set at 137. 

Before you make any Michigan State vs. Notre Dame picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six-plus years, the proprietary computer model has generated more than $1,500 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns.

Now, it has simulated Notre Dame vs. Michigan State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 70% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Notre Dame vs. Michigan State? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!