The No. 6 Houston Cougars (3-2) will take on the Notre Dame Fighting Irish (4-2) on Thursday morning in the NIL-driven 2024 Players Era Festival on the Las Vegas strip. Both teams are coming off losses in their first Players Era Festival 2024 matchup with Notre Dame losing to Rutgers, 85-84, in overtime on Tuesday and Houston falling to No. 9 Alabama, 85-80, in a battle of top-10 teams on Tuesday.

Tipoff is set for 12:30 a.m. ET on Thursday morning from MGM Grand Garden Arena in Paradise, Nev. Houston is a 16.5-point favorite in the latest Houston vs. Notre Dame odds, while the over/under is 136 points per SportsLine consensus. Before entering any Notre Dame vs. Houston picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 4 of the 2024-25 season on a 162-118 roll (+1952) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

The model has simulated Notre Dame vs. Houston 10,000 times and the results are in. We can tell you that the model is leaning Over and it's also generated a point-spread pick that is hitting in almost 60% of the time!

So who wins Houston vs. Notre Dame? And which side of the spread hits almost 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!