Notre Dame vs. Clemson odds, line, spread: Proven model reveals college football picks, predictions for Week 10, 2022

The Notre Dame Fighting Irish will take on the No. 4 Clemson Tigers at 7:30 p.m. ET on Saturday at Notre Dame Stadium. Clemson had the week off after keeping its perfect season alive in a win over then-No. 14 Syracuse two weeks ago. The Tigers are favored by 4 points in the latest Notre Dame vs. Clemson odds from Caesars Sportsbook, while the over/under is set at 43.5. 

Before you make any Clemson vs. Notre Dame picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Notre Dame vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60% of simulations! You absolutely need to see it before locking in your own picks.

So who wins Notre Dame vs. Clemson? And which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.