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Notre Dame vs. Arkansas odds, line, bets: Week 5, 2025 college football picks from proven model

SportsLine's model has locked in its Arkansas vs. Notre Dame best bets for Saturday's game

ByPublished: Sep 27, 2025 11:24AM UTC . 2 min read

The No. 22 Notre Dame Fighting Irish will look to string together back-to-back victories when they visit the Arkansas Razorbacks on Saturday. The Irish (1-2) are coming off a 56-30 win over Purdue after dropping their prior game versus another SEC team in Texas A&M. Meanwhile, the Razorbacks (2-2) are hoping to end a two-game skid and are coming off a 32-31 defeat to Memphis after squandering an 18-point lead. This will be the first ever meeting between the Irish and the Hogs.

Kickoff is at noon ET from Razorback Stadium in Fayetteville, Ark. The Fighting Irish are 4.5-point favorites in the latest Arkansas vs. Notre Dame odds, while the over/under for total points scored is 63.5. 

Before making any Notre Dame vs. Arkansas picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 35-22 combined on money-line and over/under college football picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated Arkansas vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 60% of simulations!

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Ross Kelly

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