Northwestern vs. No. 2 Purdue odds: 2024 college basketball picks, January 31 best bets by proven model

The Northwestern Wildcats meet the second-ranked Purdue Boilermakers in a key Big Ten Conference matchup set to tip at 6:30 p.m. ET on Wednesday at Mackey Arena in West Lafayette, Ind. Northwestern is 15-5 overall and 2-3 on the road, while Purdue is 19-2 overall and 10-0 at home. The Boilermakers are favored by 13 points in the latest Northwestern vs. Purdue odds, and the over/under is 141 points.

Before entering any Northwestern vs. Purdue picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 13 of the 2023-24 season on a 120-78 roll on all top-rated college basketball picks dating back to last season, returning more than $2,000 for $100 players. It is also off to a sizzling 20-7 start on top-rated spread picks this season. Anyone following has seen huge returns.

The model knows the Boilermakers are led by senior center Zach Edey, who was named the Big Ten Player of the Week on Jan. 22, the ninth time he has earned the honor, the second-most in Big Ten history. He leads the team in scoring at 23 points per game, and is averaging 11.4 rebounds, 2.3 blocks and 1.6 assists. He has scored 10 or more points in 72 consecutive games, including a 26-point, 12-rebound and four-block effort in the 68-60 win over Rutgers on Sunday.

It is also aware senior guard Boo Buie, who is in his fifth season with the Wildcats, was the main reason the Wildcats pulled off the stunner the first time the teams met in Chicago. He finished with 31 points, nine assists, four rebounds and two steals. He continues to come up big when needed. In a 96-91 overtime win over 10th-ranked Illinois last Wednesday, Buie scored 29 points and added seven assists, three rebounds and three steals.

The model has simulated Northwestern vs. Purdue 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in nearly 60% of simulations!

So who wins Northwestern vs. Purdue, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 20-7 roll on top-rated college basketball spread picks!